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BMI increase through puberty and adolescence is associated with risk of adult stroke

Artikel i vetenskaplig tidskrift
Författare Claes Ohlsson
Maria Bygdell
Arvid Sondén
Christina Jern
Annika Rosengren
Jenny Kindblom
Publicerad i Neurology
Volym 89
Nummer/häfte 4
Sidor 363-369
ISSN 0028-3878
Publiceringsår 2017
Publicerad vid Institutionen för biomedicin
Core Facilities, Bioinformatics
Centre for Bone and Arthritis Research
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 363-369
Språk en
Länkar dx.doi.org/10.1212/wnl.000000000000...
Ämnesord BODY-MASS INDEX, CORONARY-HEART-DISEASE, POPULATION-BASED COHORT, CHILDHOOD OBESITY, FOLLOW-UP, CARDIOVASCULAR MORTALITY, EXCESS, MORTALITY, SWEDISH MEN, MIDDLE-AGE, SWEDEN, Clinical Neurology
Ämneskategorier Neurologi

Sammanfattning

Objective: To evaluate the contribution of prepubertal childhood body mass index (BMI) and BMI change through puberty and adolescence, 2 distinct developmental BMI parameters, for risk of adult stroke in men. Methods: In this population-based study in Gothenburg, Sweden, men born in 1945-1961 with information on both childhood BMI at age 8 and BMI change through puberty and adolescence (BMI at age 20-BMI at age 8) were followed until December 2013 (n = 37,669). Information on stroke events was retrieved from high-quality national registers (918 first stroke events, 672 ischemic stroke events [IS], 207 intracerebral hemorrhage events [ICH]). Results: BMI increase through puberty and adolescence (hazard ratio [HR] 1.21 per SD increase; 95% confidence interval [CI] 1.14-1.28), but not childhood BMI, was independently associated with risk of adult stroke. Subanalyses revealed that BMI increase through puberty and adolescence was associated with both IS (HR per SD increase 1.19; 95% CI 1.11-1.28) and ICH (HR per SD increase 1.29; 95% CI 1.15-1.46). High BMI increase during puberty was strongly associated with increased risk of adult hypertension (odds ratio per SD increase 1.35; 95% CI 1.32-1.39). Conclusions: BMI increase through puberty and adolescence is associated with risk of adult IS and ICH in men. We propose that greater BMI increases during puberty contribute to increased risk of adult stroke at least partly via increased blood pressure.

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