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In vitro assessment of platelet concentrates with multiple electrode aggregometry.

Artikel i vetenskaplig tidskrift
Författare Caroline Andersson Shams Hakimi
Camilla Hesse
Håkan Wallén
Fredrik Boulund
Ammi Grahn
Anders Jeppsson
Publicerad i Platelets
Volym 26
Nummer/häfte 2
Sidor 132-137
ISSN 1369-1635
Publiceringsår 2015
Publicerad vid Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin
Institutionen för matematiska vetenskaper, matematisk statistik
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 132-137
Språk en
Länkar dx.doi.org/10.3109/09537104.2014.89...
Ämnesord Aggregometry; apheresis; buffy coat; platelets
Ämneskategorier Klinisk medicin

Sammanfattning

ABSTRACT Storage impairs platelet function. It was hypothesized that multiple electrode aggregometry in vitro could be used to follow aggregability in platelet concentrates over time and that the results predict the efficacy of platelet transfusion in an ex vivo transfusion model. In vitro platelet aggregability was assessed in apheresis and pooled buffy coat platelet concentrates (BCs) (n = 13 each) using multiple electrode aggregometry with different agonists 1, 3, 5 and 7 days after preparation. In the ex vivo transfusion model, whole blood samples from nine healthy volunteers were collected every second day. The samples were supplemented with stored platelets (+146 × 10(9) × l(-1)) from the same unit 1, 3, 5 and 7 days after preparation. Platelet aggregability was assessed in the concentrate and in the whole blood samples before and after platelet supplementation. There was a continuous reduction in in vitro platelet aggregability over time in both apheresis and pooled BCs. The same pattern was observed after ex vivo addition of apheresis and pooled BCs to whole blood samples. The best correlation between in vitro aggregability and changes in aggregation after addition was achieved with collagen as agonist (r = 0.67, p < 0.001). In conclusion, multiple electrode aggregometry can be used to follow aggregability in platelet concentrates in vitro, and the results predict with moderate accuracy changes in aggregation after addition of platelet concentrate to whole blood samples.

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