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Long-time persistence of superantigen-producing Staphylococcus aureus strains in the intestinal microflora of healthy infants.

Artikel i vetenskaplig tidskrift
Författare Erika Lindberg
Forough Nowrouzian
Ingegerd Adlerberth
Agnes E Wold
Publicerad i Pediatric research
Volym 48
Nummer/häfte 6
Sidor 741-7
ISSN 0031-3998
Publiceringsår 2000
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi
Sidor 741-7
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Antigens, Bacterial, analysis, Bacterial Toxins, Cohort Studies, DNA, Bacterial, analysis, Enterotoxins, biosynthesis, Feces, microbiology, Female, Humans, Hypersensitivity, Immediate, epidemiology, etiology, genetics, Infant, Infant, Newborn, Intestines, microbiology, Male, Prospective Studies, Random Amplified Polymorphic DNA Technique, Reference Values, Staphylococcus aureus, classification, immunology, isolation & purification, metabolism, Superantigens, analysis, Sweden, Time Factors
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Staphylococcus aureus has been isolated at an increasing rate from infants' stools during the last decades, but it is not known whether this species can colonize and persist in the intestinal microflora. To investigate this, 49 Swedish infants were followed prospectively from birth until 12 months of age. S. aureus was identified in a rectal swab obtained 3 d after delivery and in quantitative cultures of fecal samples collected at 1, 2, 4, and 8 weeks and at 6 and 12 months of age. A random amplified polymorphic DNA (RAPD) method was developed to distinguish individual S. aureus strains from one another and the strains were tested for production of enterotoxins A-D and TSST-1. By 3 days of age, 16% of infants had S. aureus in their intestines, which increased to 73% by 2-6 months, whereafter it decreased slightly to 53%. At the same time S. aureus population counts in colonized infants declined from an average 10(6.8) CFU/g feces during the first months of life to 10(4.0) CFU/g feces by 12 months. Colonized infants usually harbored one or two S. aureus strains in their microflora for long periods of time. Few strains were transient passengers and the median time of persistence of S. aureus strains in the microflora was several months. Of the 75 S. aureus strains identified, 43% produced one or more toxins: 13% SEA, 7% SEB, 23% SEC, 4% SED, and 11% TSST-1. Altogether, 47% of the investigated infants were colonized by a toxin-producing S. aureus during their first year of life. Despite this they were apparently healthy and did not have more gastrointestinal problems than noncolonized infants. This report is the first to show that S. aureus may be a resident member of the normal intestinal microflora in infancy.

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