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Open-label trial of atomoxetine hydrochloride in adults with ADHD.

Journal article
Authors Mats Johnson
Mats Cederlund
Maria Råstam
Björn Areskoug
Christopher Gillberg
Published in Journal of Attention Disorders
Volume 13
Issue 5
Pages 539-545
ISSN 1087-0547
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 539-545
Language en
Links dx.doi.org/10.1177/1087054709332372
Keywords Adrenergic Uptake Inhibitors, Administration & dosage, Adverse effects, Adult, Attention Deficit Disorder with Hyperactivity, Drug therapy, Drug Administration Schedule, Female, Humans, Intention to Treat Analysis, Longitudinal Studies, Male, Middle Aged, Patient Selection, Propylamines, Administration & dosage, Adverse effects, Time, Treatment Outcome
Subject categories Child and adolescent psychiatry

Abstract

Background: While atomoxetine is an established treatment for attention-deficit/hyperactivity disorder in children, few studies have examined its efficacy for adults. Methods: Open-label trial of atomoxetine in 20 individuals with ADHD, aged 19-47 years, for 10 weeks, and a total of one year for responders. Results: Ten patients met primary efficacy criteria at 10 weeks. Only one patient completed the whole study. Six patients discontinued before 10 weeks and thirteen at 10 weeks or later, mainly because of side-effects (aggression, depressed mood, raised liver enzymes, thyroid hormones, diastolic blood pressure), decreasing efficacy or non-compliance. Conclusion: Fifty percent responded to treatment, but only one patient (5%) felt sufficient improvement to continue for one year. Dosage may have been too low, and baseline impairment too high, for atomoxetine to have sufficient effect on ADHD symptoms in our group of adults. The majority had few side-effects, but several terminated treatment because of adverse effects.

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