To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Gonadectomy enhances shoc… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Gonadectomy enhances shock-induced behavioral inhibition in adult male rats: implications for impulsive behavior.

Journal article
Authors Anders I Svensson
Bo Söderpalm
Jörgen Engel
Published in Pharmacology, biochemistry, and behavior
Volume 65
Issue 4
Pages 731-6
ISSN 0091-3057
Publication year 2000
Published at Institute of Physiology and Pharmacology, Dept of Pharmacology
Pages 731-6
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Animals, Anti-Anxiety Agents, pharmacology, Conditioning, Operant, physiology, Diazepam, pharmacokinetics, pharmacology, Drinking Behavior, drug effects, physiology, Electroshock, Hypnotics and Sedatives, pharmacokinetics, pharmacology, Impulsive Behavior, psychology, Male, Orchiectomy, Postural Balance, drug effects, Rats, Rats, Sprague-Dawley, Testosterone, pharmacology, Water Deprivation, physiology
Subject categories Pharmacology, Substance Abuse

Abstract

The effects of gonadectomy on shock-induced behavioral inhibition in a modified Vogel's drinking conflict model and on diazepam-induced disinhibition and sedation were investigated in adult male rats. Gonadectomy enhanced shock-induced behavioral inhibition when determined 9, 21, 45, and 65 days, but not 3 days, after operation, without affecting shock sensitivity or drinking motivation. Testosterone-substitution for 21 days following gonadectomy prevented this enhanced inhibition without significantly affecting the behavior in sham-operated rats. Diazepam produced behavioral disinhibition both in sham-operated and gonadectomized rats. However, after the highest dose (16 mg/kg, IP) the disinhibited behavior decreased only in sham-operated animals, most likely due to sedation. Moreover, whereas there was no difference in basal rotarod-performance between controls and gonadectomized rats, the latter animals were less sensitive to diazepam-induced disruption of rotarod walking ability. Sham-operated or gonadectomized animals did not differ with respect to serum diazepam levels at the postinjection times used in the behavioral tests. Taken together, gonadectomized rats were less sensitive towards diazepam-induced sedation, possibly due to a subsensitivity at or beyond GABA(A)/benzodiazepine receptors. Furthermore, the finding that lack of testosterone enhanced shock-induced inhibition could be interpreted to reflect increased impulse control and may involve an altered activation of GABA(A)/benzodiazepine receptors.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?