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Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis.

Journal article
Authors Niklas Mattsson
M Yaong
Lars Rosengren
Kaj Blennow
Jan-Eric Månsson
Oluf Andersen
Henrik Zetterberg
Sara Haghighi
I Zho
D. Pratico
Published in Journal of internal medicine
Volume 265
Issue 4
Pages 459-64
ISSN 1365-2796
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 459-64
Language en
Links dx.doi.org/10.1111/j.1365-2796.2008...
Keywords Adolescent, Adult, Aged, Dinoprostone, cerebrospinal fluid, Female, Gas Chromatography-Mass Spectrometry, Humans, Hydroxyeicosatetraenoic Acids, cerebrospinal fluid, Male, Middle Aged, Multiple Sclerosis, cerebrospinal fluid, Severity of Illness Index, Young Adult, 15-(S)-Hydroxyeicosatetraenoic acid, arachidonic acid, biomarker, inflammation, prostaglandin E2
Subject categories Neurochemistry, Psychiatry

Abstract

OBJECTIVE: To test the hypothesis that the arachodinic acid metabolites prostaglandin E2 (PGE2) and 15-(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in cerebrospinal fluid (CSF) are elevated and reflect neuroinflammation and degenerative changes in multiple sclerosis (MS). PATIENTS AND METHODS: We measured PGE2 and 15(S)-HETE concentrations, as well as markers of axonal and astroglial injury in CSF from 46 MS patients, 46 healthy siblings and 50 controls. RESULTS: We found elevated levels of both PGE2 and 15(S)-HETE in MS compared with the control and sibling groups. Siblings had lower PGE2 levels and higher 15(S)-HETE levels than controls. There were no correlations between either PGE2 or 15(S)-HETE and clinical scores of MS severity or biochemical markers of axonal or astroglial injury. CONCLUSION: These data suggest no direct involvement of PGE2 and 15(S)-HETE in the MS disease process. Rather, the elevated levels reflect a general up-regulation of arachidonic acid metabolism and neuroinflammation.

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