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White matter damage after chronic subclinical inflammation in newborn mice.

Journal article
Authors Xiaoyang Wang
Gunnel Hellgren
Chatarina Löfqvist
Wenli Li
Ann Hellström
Henrik Hagberg
Carina Mallard
Published in Journal of child neurology
Volume 24
Issue 9
Pages 1171-8
ISSN 1708-8283
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Physiology
Institute of Clinical Sciences
Pages 1171-8
Language en
Subject categories Ophthalmology


Preterm infants exposed to inflammation are at increased risk of white matter injury and/or cerebral palsy. To investigate the effect of chronic inflammation on the developing white matter, we administered low-dose lipopolysaccharide once a day from postnatal days 3 to 11, examined white matter changes at postnatal day 12, and monitored serum levels of insulin-like growth factor 1 and insulin-like factor binding protein-3. A single injection of lipopolysaccharide decreased the serum insulin-like growth factor 1 level but not the insulin-like factor binding protein-3 level. At postnatal day 12, quantification of immunohistochemical staining for axonal, myelin, and oligodendrocyte markers revealed impaired myelination in subcortical white matter. In addition, brain gray matter volume decreased and spleen and liver weight increased at postnatal day 12. These data suggest chronic subclinical inflammation hampers development of white and gray matter in early life, which may be associated with insulin-like growth factor 1 deficiency.

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