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Dual-conjugate adaptive optics for wide-field high-resolution retinal imaging.

Journal article
Authors Jörgen Thaung
Per Knutsson
Zoran Popovic
Mette Owner-Petersen
Published in Optics express
Volume 17
Issue 6
Pages 4454-67
ISSN 1094-4087
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 4454-67
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Computer Simulation, Fovea Centralis, anatomy & histology, Fundus Oculi, Humans, Imaging, Three-Dimensional, methods, Ophthalmology, instrumentation, methods, Optics and Photonics, instrumentation, Retina, anatomy & histology, Spectrum Analysis, Vision, color, and visual optics : Vision system - noninvasive assessment, Vision, color, and visual optics : Ophthalmic optics and devices, Vision, color, and visual optics : Visual optics, modeling, Vision, color, and visual optics : Visual optics, ophthalmic instrumentation, Imaging systems : Active or adaptive optics
Subject categories Optics, Ophthalmology

Abstract

We present analysis and preliminary laboratory testing of a real-time dual-conjugate adaptive optics (DCAO) instrument for ophthalmology that will enable wide-field high resolution imaging of the retina in vivo. The setup comprises five retinal guide stars (GS) and two deformable mirrors (DM), one conjugate to the pupil and one conjugate to a plane close to the retina. The DCAO instrument has a closed-loop wavefront sensing wavelength of 834 nm and an imaging wavelength of 575 nm. It incorporates an array of collimator lenses to spatially filter the light from all guide stars using one adjustable iris, and images the Hartmann patterns of multiple reference sources on a single detector. Zemax simulations were performed at 834 nm and 575 nm with the Navarro 99 and the Liou- Brennan eye models. Two correction alternatives were evaluated; conventional single conjugate AO (SCAO, using one GS and a pupil DM) and DCAO (using multiple GS and two DM). Zemax simulations at 575 nm based on the Navarro 99 eye model show that the diameter of the corrected field of view for diffraction-limited imaging (Strehl >or= 0.8) increases from 1.5 deg with SCAO to 6.5 deg using DCAO. The increase for the less stringent condition of a wavefront error of 1 rad or less (Strehl >or= 0.37) is from 3 deg with SCAO to approximately 7.4 deg using DCAO. Corresponding results for the Liou-Brennan eye model are 3.1 deg (SCAO) and 8.2 deg (DCAO) for Strehl >or= 0.8, and 4.8 deg (SCAO) and 9.6 deg (DCAO) for Strehl >or= 0.37. Potential gain in corrected field of view with DCAO is confirmed both by laboratory experiments on a model eye and by preliminary in vivo imaging of a human eye.

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