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Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I.

Journal article
Authors Chatarina Löfqvist
Ingrid Hansen-Pupp
Eva M. Andersson
Kristina Holm
Lois E H Smith
David Ley
Ann Hellström
Published in Archives of ophthalmology
Volume 127
Issue 5
Pages 622-7
ISSN 1538-3601
Publication year 2009
Published at Institute of Medicine, School of Public Health and Community Medicine
Department of Economics, Statistical Research Unit
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 622-7
Language en
Keywords Algorithms, Biological Markers, blood, Birth Weight, physiology, False Positive Reactions, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, blood, Insulin-Like Growth Factor Binding Protein 3, blood, Insulin-Like Growth Factor I, analysis, Male, Predictive Value of Tests, Prospective Studies, Radioimmunoassay, Reproducibility of Results, Retinopathy of Prematurity, blood, etiology, Risk Factors, Sensitivity and Specificity
Subject categories Ophthalmology, Public health medicine research areas


OBJECTIVE: To validate in a prospective study the surveillance algorithm WINROP for detecting infants at risk for proliferative retinopathy of prematurity (ROP). METHODS: Fifty preterm infants with a mean gestational age of 26 weeks were included. In the first step of WINROP, weekly measures of body weight and serum insulinlike growth factor I (IGF-I) level from birth until postmenstrual age 36 weeks are entered and compared with expected development. If any of the variables show a negative deviation to a certain degree, an alarm is given. In the second step, gestational age, birth weight, and IGF binding protein 3 level are entered. RESULTS: The WINROP algorithm identified all children (100% sensitivity) who were diagnosed with proliferative ROP 1.1 to 21.6 weeks later. No infants with no alarm or with alarm at low risk developed proliferative ROP. Alarm at high risk before postmenstrual age 32 weeks was given for 22 of 50 infants (44%); 9 of these infants developed proliferative ROP (54% specificity), of whom 8 were treated. CONCLUSION: The WINROP algorithm may be a useful tool for modification of ROP screening.

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