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Cystatin C in cerebrospinal fluid and multiple sclerosis.

Journal article
Authors Sarah Hansson
Anja Hviid Simonsen
Henrik Zetterberg
Oluf Andersen
Sara Haghighi
Inger Fagerberg
Ulf Andreasson
Ann Brinkmalm-Westman
Anders Wallin
Ulla Rüetschi
Kaj Blennow
Published in Annals of neurology
Volume 62
Issue 2
Pages 193-6; discussion 205
ISSN 0364-5134
Publication year 2007
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 193-6; discussion 205
Language en
Links dx.doi.org/10.1002/ana.20945
Keywords Amino Acid Sequence, Artifacts, Biological Markers, cerebrospinal fluid, Cystatin C, Cystatins, cerebrospinal fluid, chemistry, genetics, Drug Storage, Freezing, Humans, Molecular Weight, Multiple Sclerosis, cerebrospinal fluid, Osmolar Concentration, Peptide Fragments, cerebrospinal fluid, chemistry, genetics, Protein Isoforms, cerebrospinal fluid, chemistry, genetics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Time Factors
Subject categories Psychiatry

Abstract

OBJECTIVE: A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5 kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS). METHODS: Surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects. RESULTS: Full-length CysC (13.4 kDa) concentration was similar in MS and control samples. The 12.5 kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C. INTERPRETATION: The 12.5 kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS.

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