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Expression of zinc transporter ZnT7 in mouse superior cervical ganglion.

Journal article
Authors Hui-Ling Gao
He Xu
Xin Wang
Annica Dahlström
Liping Huang
Zhan-You Wang
Published in Autonomic neuroscience : basic & clinical
Volume 140
Issue 1-2
Pages 59-65
ISSN 1566-0702
Publication year 2008
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 59-65
Language en
Links dx.doi.org/10.1016/j.autneu.2008.04...
Keywords Animals, Autoradiography, Cation Transport Proteins, metabolism, Cell Compartmentation, physiology, Golgi Apparatus, metabolism, ultrastructure, Immunohistochemistry, Male, Mice, Neurochemistry, Neurons, cytology, metabolism, Superior Cervical Ganglion, cytology, metabolism, Zinc, metabolism
Subject categories Histology

Abstract

The superior cervical ganglion (SCG) neurons contain a considerable amount of zinc ions, but little is known about the zinc homeostasis in the SCG. It is known that zinc transporter 7 (ZnT7, Slc30a7), a member of the Slc30 ZnT family, is involved in mobilizing zinc ions from the cytoplasm into the Golgi apparatus. In the present study, we examined the expression and localization of ZnT7 and labile zinc ions in the mouse SCG using immunohistochemistry, Western blot and in vivo zinc selenium autometallography (AMG). Our immunohistochemical analysis revealed that the ZnT7 immunoreactivity in the SCG neurons was predominately present in the perinuclear region of the neurons, suggesting an affiliation to the Golgi apparatus. The Western blot results verified that ZnT7 protein was expressed in the mouse SCGs. The AMG reaction product was shown to have a similar distribution as ZnT7 immunoreactivity. These observations support the notion that ZnT7 may participate in zinc transport, storage, and incorporation of zinc into zinc-binding proteins in the Golgi apparatus of mouse SCG neurons.

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