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Peripheral projections of NESP55 containing neurons in the rat sympathetic ganglia.

Journal article
Authors Yongling Li
Annica Dahlström
Published in Autonomic neuroscience : basic & clinical
Volume 141
Issue 1-2
Pages 1-9
ISSN 1566-0702
Publication year 2008
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 1-9
Language en
Keywords Animals, Calcitonin Gene-Related Peptide, metabolism, GTP-Binding Protein alpha Subunits, Gs, metabolism, Ganglia, Sympathetic, metabolism, Iris, innervation, metabolism, Lymph Nodes, innervation, metabolism, Male, Microinjections, Microscopy, Fluorescence, Nerve Fibers, physiology, Neural Pathways, physiology, Neurons, metabolism, physiology, Neuropeptide Y, metabolism, Rats, Rats, Sprague-Dawley, Skin, innervation, metabolism, Stellate Ganglion, metabolism, Submandibular Gland, innervation, metabolism, Synaptic Transmission, physiology, Thyroid Gland, innervation, metabolism
Subject categories Histology


The peripheral projections of neurons expressing neuroendocrine secretory protein 55 (NESP55), a novel member of the chromogranin family, were studied by retrograde tracing technique. It was found that NESP55 positive neurons in the rat superior cervical ganglion projected to a number of targets including the submandibular gland, the cervical lymph nodes, the forehead skin, the iris, but not to the thyroid. Among these NESP55 positive target-projecting neurons, a subpopulation contained neuropeptide Y (NPY), a vasoconstrictor. Forepaw pad projecting neurons were found exclusively in the stellate ganglion, almost all of which (approximately 90%) were immunoreactive to NESP55. Colocalization of NESP55 and calcitonin gene-related peptide (CGRP), a peptide involved in sudomotor effects, was observed in a subpopulation of these paw pad projecting neurons, as was colocalization of NESP55 and NPY. The data suggest that NESP55 may have a functional role in some populations of sympathetic neurons.

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