To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Axonal transport of zinc … - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Axonal transport of zinc transporter 3 and zinc containing organelles in the rodent adrenergic system.

Journal article
Authors Zhan-You Wang
Annica Dahlström
Published in Neurochemical research
Volume 33
Issue 12
Pages 2472-9
ISSN 1573-6903
Publication year 2008
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 2472-9
Language en
Keywords Animals, Axons, Carrier Proteins, metabolism, Cation Transport Proteins, metabolism, Membrane Proteins, metabolism, Mice, Organelles, metabolism, Rats, Receptors, Adrenergic, metabolism, Zinc, metabolism
Subject categories Histology


Zinc is the second most abundant trace metal (after iron) in mammalian tissues, and it is an essential element for growth, development, DNA synthesis, immunity, and other important cellular processes. A considerable amount of zinc in the brain exists as a pool of free or loosely bound zinc ions in synaptic vesicles with zinc transporter 3 (ZnT3) in their membranes. Here we demonstrate that also in the peripheral sympathetic nervous system zinc handling neurons exist. In autonomic ganglia of rats and mice a subset of neuronal cell bodies contain zinc, visualized by the autometallographic (AMG) and TSQ histochemical methods. The Zn-transporter 3 is, as shown by immunofluorescence, also present in tyrosine hydroxylase (TH)-positive neurons, but rarely in cell bodies with neuropeptide Y (NPY)-immunoreactivity (IR). In axons of crush-operated sciatic nerves a rapid bidirectional accumulation of AMG granules occurred. Also ZnT3-IR was found to accumulate rapidly in anterograde as well as retrograde direction, colocalized with TH-IR. So far nerve terminals with ZnT3-IR have not been observed. The functional significance of zinc ions in the sympathetic system is not known.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?