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Oxygen radical production in leukocytes and disease severity in multiple sclerosis.

Journal article
Authors Natalia Mossberg
Charlotta Movitz
Kristoffer Hellstrand
Tomas Bergström
Staffan Nilsson
Oluf Andersen
Published in Journal of neuroimmunology
Volume 213
Issue 1-2
Pages 131-134
ISSN 1872-8421
Publication year 2009
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Department of Mathematical Sciences, Mathematical Statistics
Institute of Biomedicine, Department of Infectious Medicine
Pages 131-134
Language en
Keywords Leukocytes, Multiple Sclerosis, immunology,NADPH Oxidase, Immunology, Phagocytes, immunology,Reactive Oxygen Species, Respiratory Burst, Severity
Subject categories Medical and Health Sciences


This study investigated the relationship between the formation of NADPH oxidase-dependent oxygen radicals in peripheral blood leukocytes ('respiratory burst') and disease severity in patients with multiple sclerosis (MS). Oxygen radical production was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) or phorbol myristate acetate (PMA) and was assessed by quantifying superoxide anion, i.e. the initial radical formed by the NADPH oxidase. Disease severity was evaluated using the Multiple Sclerosis Severity Score (MSSS). In patients with severe disease, the production of superoxide anion was significantly lower for all three inducers of radical formation (p=0.04-0.004). Our findings are supportive of a protective role of oxygen radicals in autoimmunity.

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