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Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice.

Journal article
Authors Klara Sjögren
Mohammad Bohlooly-Yeganeh
Bob Olsson
Karen T Coschigano
Jan Törnell
Subburaman Mohan
Olle Isaksson
G Baumann
John J Kopchick
Claes Ohlsson
Published in Biochemical and biophysical research communications
Volume 267
Issue 2
Pages 603-8
ISSN 0006-291X
Publication year 2000
Published at Institute of Internal Medicine, Dept of Medicine
Institute of Internal Medicine
Institute of Physiology and Pharmacology, Dept of Physiology
Pages 603-8
Language en
Keywords Animals, Base Sequence, Biological Markers, blood, Bone Density, genetics, physiology, Bone Development, genetics, physiology, DNA Primers, genetics, Femur, growth & development, Growth Hormone, physiology, Insulin-Like Growth Factor I, genetics, metabolism, Male, Mice, Mice, Knockout, Organ Size, Organ Specificity, RNA, Messenger, genetics, metabolism, Receptors, Somatotropin, deficiency, genetics, Tibia, growth & development
Subject categories Medical and Health Sciences


Growth hormone (GH) is important for skeletal growth as well as for a normal bone metabolism in adults. The skeletal growth and adult bone metabolism was studied in mice with an inactivated growth hormone receptor (GHR) gene. The lengths of femur, tibia, and crown-rump were, as expected, decreased in GHR-/- mice. Unexpectedly, GHR-/- mice displayed disproportional skeletal growth reflected by decreased femur/crown-rump and femur/tibia ratios. GHR-/- mice demonstrated decreased width of the growth plates in the long bones and disturbed ossification of the proximal tibial epiphysis. Furthermore, the area bone mineral density (BMD) as well as the bone mineral content (BMC)/body weight were markedly decreased in GHR-/- mice. The decrease in BMC in GHR-/- mice was not due to decreased trabecular volumetric BMD but to a decreased cross-sectional cortical bone area In conclusion, GHR-/- mice demonstrate disproportional skeletal growth and markedly decreased bone mineral content.

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