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The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: an animal model of premenstrual irritability?

Journal article
Authors Hoi-Por Ho
Marie Olsson
Lars Westberg
Jonas Melke
Elias Eriksson
Published in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume 24
Issue 5
Pages 502-10
ISSN 0893-133X
Publication year 2001
Published at Institute of Physiology and Pharmacology, Dept of Pharmacology
Pages 502-10
Language en
Links dx.doi.org/10.1016/S0893-133X(00)00...
Keywords Aggression, drug effects, physiology, Animals, Behavior, Animal, drug effects, physiology, Brain, drug effects, metabolism, physiopathology, Disease Models, Animal, Estradiol, pharmacology, Estrus, drug effects, physiology, Female, Fluoxetine, pharmacology, Ovariectomy, Premenstrual Syndrome, drug therapy, metabolism, physiopathology, Progesterone, pharmacology, Rats, Rats, Wistar, Serotonin, metabolism, Serotonin Uptake Inhibitors, pharmacology
Subject categories Pharmacology and Toxicology

Abstract

The aggressive behavior displayed by some (but not all) female Wistar rats when an unfamiliar rat is being introduced into their home cage (the resident intruder paradigm) was found to be higher in non-receptive phases (metestrus, diestrus) than in the receptive phases (proestrus, estrus) of the estrus cycle, and effectively reduced by ovariectomy. When removal of the ovaries was followed by administration of estradiol and progesterone, in a regimen mimicking the normal cyclical release of these hormones, aggressive behavior was elicited, two days after estrus, in animals that had displayed aggressive behavior before ovariectomy, but not in those that had not. Short-term administration of a serotonin reuptake inhibitor (fluoxetine hydrochloride; 10 mg/kg, i.p.; 4-5 days) reduced both the aggressive behavior displayed during the diestrus phase by normally cycling rats, and the aggressive behavior elicited by administration of estradiol plus progesterone after ovariectomy. It is suggested that the aggressive behavior displayed by the female Wistar rat in the resident intruder paradigm may serve as an animal model of premenstrual dysphoria.

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