To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Bilateral diffusion tenso… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Bilateral diffusion tensor abnormalities of temporal lobe and cingulate gyrus white matter in children with temporal lobe epilepsy.

Journal article
Authors Daniel Nilsson
Cristina Go
James T Rutka
Bertil Rydenhag
Donald J Mabbott
O Carter Snead
Charles R Raybaud
Elysa Widjaja
Published in Epilepsy research
Volume 81
Issue 2-3
Pages 128-35
ISSN 0920-1211
Publication year 2008
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 128-35
Language en
Links dx.doi.org/10.1016/j.eplepsyres.200...
Keywords Temporal lobe epilepsy, Pediatric, White matter, Diffusion tensor imaging, MRI
Subject categories Medical and Health Sciences

Abstract

PURPOSE: Bilateral diffusion tensor imaging (DTI) abnormalities have been reported in the white matter associated to the hippocampus in adults with mesial temporal lobe epilepsy (TLE). In children with a shorter duration of epilepsy, such changes may not have yet emerged. The aim of this study was to investigate interictal changes in the temporal lobe white matter (TLWM) and cingulate gyrus white matter (CGWM) of children with TLE using DTI. METHODS: DTI was performed in eight children with TLE and 10 healthy, age-matched controls. Fractional anisotropy (FA), trace, parallel (lambda(||)) and perpendicular (lambda( perpendicular)) diffusivity were calculated for a volume of interest in the TLWM and CGWM on the seizure focus side and the contralateral side. Data were compared for differences between sides for patients and between patients and controls. RESULTS: There was no significant difference in FA, trace, lambda(||) and lambda( perpendicular) between TLWM and CGWM on the seizure focus side versus the contralateral side in TLE patients. Increased diffusivity, lambda(||) and lambda( perpendicular) within the TLWM and CGWM were found in TLE patients compared to controls, but no significant difference in FA was seen. CONCLUSIONS: Bilaterally increased diffusivity, lambda(||) and lambda( perpendicular) in the white matter in children with TLE may be related to seizure induced functional or structural changes. The preserved FA in our pediatric cohort is in contrast to the reduced FA in the white matter of adults with TLE and may relate to differences in the duration of epilepsy or in the vulnerability of white matter to seizures.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?