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Interneuronal activity in reflex pathways from group II muscle afferents is monitored by dorsal spinocerebellar tract neurons in the cat.

Journal article
Authors Elzbieta Jankowska
Anna Puczynska
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume 28
Issue 14
Pages 3615-22
ISSN 1529-2401
Publication year 2008
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 3615-22
Language en
Keywords Action Potentials, physiology, radiation effects, Animals, Cats, Electric Stimulation, methods, Inhibitory Postsynaptic Potentials, physiology, radiation effects, Interneurons, physiology, Laminectomy, methods, Motor Neurons, physiology, Muscle Fibers, Fast-Twitch, physiology, radiation effects, Neural Inhibition, physiology, Peripheral Nerves, physiology, radiation effects, Reaction Time, physiology, radiation effects, Reflex, physiology, Spinal Cord, cytology, Spinocerebellar Tracts, cytology, Time Factors
Subject categories Physiology, Neurophysiology


The main aim of the study was to investigate whether group II muscle afferents contribute to the inhibition of dorsal spinocerebellar tract (DSCT) neurons and thereby modulate information provided by these neurons in the cat. In intracellular recordings, we found disynaptic IPSPs from group II afferents in the majority of DSCT neurons, most often in parallel with IPSPs evoked from group I afferents. In an attempt to identify interneurons that mediate these IPSPs, the second aim of the study, laminas IV-VII in midlumbar segments were searched for interneurons antidromically activated by stimuli applied within Clarke's column. Such interneurons were found in regions in which focal field potentials were evoked by group I and II afferents, or ventral to them, and most were coexcited by these afferents. The input to these interneurons and their location indicate that they belonged to the previously identified population of premotor interneurons in disynaptic pathways between group I and II afferents and hindlimb motoneurons. The study leads thus to the conclusion that inhibitory actions of group II afferents on DSCT neurons are collateral to actions on motoneurons and that DSCT neurons monitor inhibitory actions of group II afferents on motoneurons as closely as they monitor actions of group I afferents. The results also indicate that interneurons mediating disynaptic reflex actions from tendon organ (group Ib) afferents and those mediating disynaptic actions from secondary muscle spindle (group II) afferents to motoneurons may be parts and parcel of the same interneuronal population rather than constitute distinct interneuronal populations.

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