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Cerebrospinal fluid protein reactions during non-neurological surgery.

Journal article
Authors Rolf Anckarsäter
N Vasic
L Jidéus
M Kristiansson
Henrik Zetterberg
Kaj Blennow
Henrik Anckarsäter
Published in Acta neurologica Scandinavica
Volume 115
Issue 4
Pages 254-9
ISSN 0001-6314
Publication year 2007
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 254-9
Language en
Keywords Aged, Aged, 80 and over, Arthroplasty, Replacement, Knee, adverse effects, Cerebrospinal Fluid Proteins, metabolism, Female, Humans, Intramolecular Oxidoreductases, blood, cerebrospinal fluid, Intraoperative Period, Lipocalins, Male, Middle Aged, Postoperative Period, Serum Albumin, metabolism, Stress, Physiological, blood, cerebrospinal fluid, etiology, beta 2-Microglobulin, blood, cerebrospinal fluid
Subject categories Medical and Health Sciences


OBJECTIVE: To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. SUBJECTS AND METHODS: Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. RESULTS: Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (betaTP) remained unchanged. CONCLUSIONS: Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.

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