To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

The local and systemic T-… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10.

Journal article
Authors Samuel B Lundin
Karin Enarsson
Bert Kindlund
Anna Lundgren
Erik Johnsson
Marianne Quiding-Järbrink
Ann-Mari Svennerholm
Published in Clinical immunology (Orlando, Fla.)
Volume 125
Issue 2
Pages 205-13
ISSN 1521-6616
Publication year 2007
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Clinical Sciences
Pages 205-13
Language en
Keywords Adenocarcinoma, immunology, microbiology, Adult, Aged, Aged, 80 and over, Cell Proliferation, Female, Flow Cytometry, Gastric Mucosa, immunology, microbiology, Helicobacter Infections, blood, immunology, microbiology, Helicobacter pylori, immunology, Humans, Interferon-gamma, immunology, Interleukin-10, biosynthesis, genetics, immunology, Male, Middle Aged, RNA, Messenger, chemistry, genetics, Reverse Transcriptase Polymerase Chain Reaction, Statistics, Nonparametric, Stomach Neoplasms, immunology, microbiology, T-Lymphocytes, immunology, microbiology
Subject categories Immunology in the medical area


Helicobacter pylori causes a life-long infection that may lead to development of gastric adenocarcinoma (GC) and thereby cause major worldwide health problems. The present study was designed to study whether those that develop GC have an altered immune response to H. pylori compared to individuals that remain asymptomatic. When stimulated with H. pylori antigens, T cells from both peripheral blood and gastric mucosa of H. pylori-infected GC patients produced high amounts of IL-10, while the IL-10 production from blood T cells of H. pylori-infected asymptomatic subjects was low. Furthermore, mRNA levels of IL-10 were increased in the gastric mucosa of GC patients. In addition, the frequency of activated CD8(+) T cells was markedly reduced in stomach mucosa of patients with GC compared to asymptomatic individuals. We propose that the increased production of the suppressive cytokine IL-10 in H. pylori-infected GC patients leads to a diminished cytotoxic anti-tumour T-cell response in the stomach, which may contribute to tumour progression in subjects suffering from GC.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?