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Qualitative and quantitative observations of bone tissue reactions to anodised implants.

Journal article
Authors Young-Taeg Sul
Carina B. Johansson
Kerstin Röser
Tomas Albrektsson
Published in Biomaterials
Volume 23
Issue 8
Pages 1809-17
ISSN 0142-9612
Publication year 2002
Published at Institute of Surgical Sciences, Department of Biomaterials
Pages 1809-17
Language en
Keywords Titanium implants; Titanium oxide properties; Bone; Histomorphometry; Enzyme histochemistry
Subject categories Surface engineering, Biomaterials


Research projects focusing on biomaterials related factors; the bulk implant material, the macro-design of the implant and the microsurface roughness are routinely being conducted at our laboratories. In this study, we have investigated the bone tissue reactions to turned commercially pure (c.p.) titanium implants with various thicknesses of the oxide films after 6 weeks of insertion in rabbit bone. The control c.p. titanium implants had an oxide thickness of 17-200 nm while the test implants revealed an oxide thickness between 600 and 1000 nm. Routine histological investigations of the tissue reactions around the implants and enzyme histochemical detections of alkaline and acid phosphatase activities demonstrated similar findings around both the control and test implants. In general, the histomorphometrical parameters (bone to implant contact and newly formed bone) revealed significant quantitative differences between the control and test implants. The test implants demonstrated a greater bone response histomorphometrically than control implants and the osteoconductivity was more pronounced around the test implant surfaces. The parameters that differed between the implant surfaces, i.e. the oxide thickness, the pore size distribution, the porosity and the crystallinity of the surface oxides may represent factors that have an influence on the histomorphometrical results indicated by a stronger bone tissue response to the test implant surfaces, with an oxide thickness of more than 600 nm.

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