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Oral immunization with HpaA affords therapeutic protective immunity against H. pylori that is reflected by specific mucosal immune responses.

Journal article
Authors Johanna Nyström
Ann-Mari Svennerholm
Published in Vaccine
Volume 25
Issue 14
Pages 2591-8
ISSN 0264-410X
Publication year 2007
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 2591-8
Language en
Links dx.doi.org/10.1016/j.vaccine.2006.1...
Keywords Adhesins, Bacterial, immunology, Administration, Oral, Animals, Antibodies, Bacterial, biosynthesis, Bacterial Vaccines, immunology, Cytokines, biosynthesis, Female, Helicobacter Infections, prevention & control, Helicobacter pylori, immunology, Immunity, Mucosal, Immunization, Immunoglobulin A, Secretory, biosynthesis, Mice, Mice, Inbred C57BL, Stomach, microbiology
Subject categories Microbiology in the medical area

Abstract

In the present study, we evaluated the capacity of Helicobacter pylori adhesin A (HpaA), a H. pylori specific colonization factor, to induce therapeutic protection against H. pylori infection in mice. We found that oral immunization of H. pylori infected mice with HpaA induced protection, i.e. significant reduction in bacterial load in the stomach. This was even more pronounced when a combination of HpaA and urease was used. The protection was strongly related to specific mucosal CD4+ T cell responses with a Th1 profile as well as to mucosal IgA responses locally in the stomach. These findings suggest that HpaA is a promising vaccine candidate antigen for use in a therapeutic vaccine against H. pylori.

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