To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Disease burden due to ent… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh.

Journal article
Authors Firdausi Qadri
Amit Saha
Tanvir Ahmed
Abdullah Al Tarique
Yasmin Ara Begum
Ann-Mari Svennerholm
Published in Infection and immunity
Volume 75
Issue 8
Pages 3961-8
ISSN 0019-9567
Publication year 2007
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 3961-8
Language en
Keywords ABO Blood-Group System, Bacterial Toxins, biosynthesis, Bangladesh, epidemiology, Breast Feeding, Diarrhea, Infantile, epidemiology, microbiology, Enterotoxins, biosynthesis, Enzyme-Linked Immunosorbent Assay, Escherichia coli, classification, isolation & purification, Escherichia coli Infections, blood, epidemiology, microbiology, pathology, Escherichia coli Proteins, biosynthesis, Feces, microbiology, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Pregnancy, Rotavirus, isolation & purification, Rotavirus Infections, epidemiology, Seasons, Urban Population
Subject categories Microbiology in the medical area


A cohort of 321 children was followed from birth up to 2 years of age to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. The average number of diarrheal days and incidence rates were 6.6 and 2.3/child/year, respectively. ETEC was the most common pathogen and was isolated in 19.5% cases, with an incidence of 0.5 episode/child/year. The prevalence of rotavirus diarrhea was lower (10%). ETEC expressing the heat-stable enterotoxin (ST) was predominant. Strains isolated from diarrheal cases were positive for colonization factors (CFs) in higher frequency (66%) than from healthy children (33%) (P < 0.001). The heat-labile toxin (LT)-positive strains from healthy children were more often CF negative (92%) than those isolated from children with diarrhea (73%) (P < 0.001). In children with symptomatic or asymptomatic infections by CFA/I, CS1 plus CS3, CS2 plus CS3, or CS5 plus CS6 strains, a repeat episode of diarrhea or infection by the homologous CF type was uncommon. Repeat symptomatic infections were noted mostly for LT- and ST-expressing ETEC. ETEC diarrhea was more prevalent in children in the A and AB groups than in those in the O blood group (P = 0.032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?