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Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country.

Journal article
Authors Taufiqur Rahman Bhuiyan
Firdausi Qadri
Prodip Kumar Bardhan
Mian Mashhud Ahmad
Bert Kindlund
Ann-Mari Svennerholm
Anna Lundgren
Published in FEMS immunology and medical microbiology
Volume 54
Issue 1
Pages 70-9
ISSN 0928-8244
Publication year 2008
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 70-9
Language en
Links dx.doi.org/10.1111/j.1574-695X.2008...
Keywords Adolescent, Adult, Animals, Antibodies, Bacterial, analysis, immunology, B-Lymphocytes, immunology, Bangladesh, epidemiology, Developed Countries, Developing Countries, Duodenum, immunology, Female, Helicobacter Infections, epidemiology, immunology, microbiology, Helicobacter pylori, immunology, Humans, Immunity, Mucosal, Intestinal Mucosa, immunology, Male, Middle Aged, Pyloric Antrum, immunology, Sweden, epidemiology, T-Lymphocytes, immunology
Subject categories Microbiology in the medical area

Abstract

Helicobacter pylori is highly endemic in developing countries, but comparatively little is known about mucosal immune responses to H. pylori in these settings. Therefore, we have compared B- and T-cell responses, with a focus on the gastrointestinal mucosa, in H. pylori-infected adults in a developing (Bangladesh) and a developed (Sweden) country. We found comparable numbers of CD19(+) B cells and CD4 (+)T cells and similar levels of H. pylori-specific IgA antibodies in gastric mucosa from Bangladeshi and Swedish volunteers. However, about threefold higher numbers of CD19(+) B cells and 12-fold increased levels of H. pylori-specific IgA antibodies were found in the duodenum of Bangladeshi subjects. The gastric and duodenal immune responses in Bangladeshi asymptomatic carriers and duodenal ulcer patients were comparable. Bangladeshi subjects had about twofold lower titers of H. pylori-specific IgA and IgG antibodies in the circulation compared with Swedish volunteers. In conclusion, our findings suggest that Bangladeshi individuals have comparable gastric immune responses, but lower systemic antibody responses to H. pylori, compared with Swedish volunteers. Increased inflammation is present in the duodenum of Bangladeshi volunteers, maybe as a result of frequent exposure to enteric infections in these individuals.

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