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Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia.

Journal article
Authors Jessica Westerlund
Louise Andersson
Therese Carlsson
Pietro Zoppoli
Henrik Fagman
Mikael Nilsson
Published in Developmental dynamics : an official publication of the American Association of Anatomists
Volume 237
Issue 12
Pages 3820-9
ISSN 1058-8388
Publication year 2008
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 3820-9
Language en
Links dx.doi.org/10.1002/dvdy.21772
Subject categories Biological Sciences, Cell and Molecular Biology

Abstract

The LIM homeodomain transcription factor Isl1 was investigated in mouse thyroid organogenesis. All progenitor cells of the midline thyroid diverticulum and lateral primordia (ultimobranchial bodies) expressed Isl1. This pattern persisted until the growing anlagen fused at embryonic day (E) 13.5. In Isl1 null mutants thyroid progenitors expressing Nkx2.1 and Pax8 were readily specified in the anterior endoderm but the size of the thyroid rudiment was reduced. In late development, only immature C-cells expressed Isl1. In the adult gland the number of Isl1+ cells was small compared with cells expressing calcitonin. Analysis of microarray profiles indicated a higher level of Isl1 expression in medullary thyroid carcinomas than in tumors derived from follicular cells. Together, these findings suggest that Isl1 may be a novel regulator of thyroid development before terminal differentiation of the endocrine cell types. Isl1 is an embryonic C-cell precursor marker that may be relevant also in cancer developed from the mature C-cell.

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