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Intrathecal immunoactivation in patients with HIV-1 infection is reduced by zidovudine but not by didanosine

Journal article
Authors Lars Hagberg
Gunnar Norkrans
Magnus Gisslén
Helmut Wachter
Dietmar Fuchs
Bo Svennerholm
Published in Scand J Infect Dis
Volume 28
Issue 4
Pages 329-33
Publication year 1996
Published at Institute of Internal Medicine, Dept of Infectious Diseases
Institute of Laboratory Medicine, Dept of Clinical Virology
Pages 329-33
Language en
Links Http://
Keywords Adult, Aged, Anti-HIV Agents/*therapeutic use, Biopterin/*analogs & derivatives/cerebrospinal fluid, Didanosine/*therapeutic use, HIV Infections/cerebrospinal fluid/*drug therapy, *Hiv-1, Humans, Immunoglobulin G/cerebrospinal fluid, Middle Aged, Neopterin, Zidovudine/*therapeutic use
Subject categories Microbiology in the medical area


The effect of zidovudine and didanosine on the cerebrospinal fluid (CSF) concentrations of neopterin was studied in 12 patients with human immunodeficiency virus type-1 (HIV-1) infection 3-12 months after initiation of antiretroviral therapy. Ten treatment periods on zidovudine and 7 on didanosine were analysed. The CSF concentrations of neopterin decreased by 63% (from 29.6 to 12.9 nmol/l, p < 0.01) during zidovudine but increased by 15% (from 22.6 to 25.9 nmol/l, not significant during didanosine treatment. The CSF monocytic cell count decreased during zidovudine but increased during didanosine treatment. The results suggest that zidovudine but not didanosine reduces intrathecal immunoactivation during HIV-1 infection.

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