To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Associations between pers… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Associations between personality traits and polymorphisms in genes related to inflammation in women

Authors Petra Suchankova
Susanne Henningsson
Fariba Baghaei
Roland Rosmond
Göran Holm
Elias Eriksson
Agneta Ekman
Published in 49th Annual meeting of the Scandinavian College of Neuro-Psychopharmacology
Publication year 2008
Published at Institute of Medicine
Institute of Neuroscience and Physiology, Department of Pharmacology
Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Subject categories Medical Genetics


Both inflammation and certain personality traits have been associated with depression; however, the mechanisms underlying these connections are unknown. The present study investigates two single nucleotide polymorphisms located in genes that are associated with inflammation with regards to personality traits in order to examine the possible involvement of inflammation in general brain functions. The first polymorphism, +1444C>T (rs1130864), is located in the gene coding for C-reactive protein (CRP), a marker of low-grade inflammation, and has previously been linked to raised serum levels of high-sensitivity CRP. The second polymorphism, Y402H (rs1061170), is located in the gene coding for complement factor H (CFH), an important regulator of the complement system. CRP binds to CFH and thereby augments the ability of CFH to down regulate the alternative pathway of complement. The 402H allele has consistently been associated with age-related macular degeneration and was recently linked to Alzheimer’s disease. The population consisted of 270 women recruited from the population registry. These women were assessed by means of Karolinska Scale of Personality, a self-reported inventory. The +1444T allele was significantly associated with higher scores in the personality traits impulsiveness, monotony avoidance and social desirability (p=0.0016, p=0.016 and p=0.048, respectively). The 402H polymorphism was significantly associated with higher levels of the personality trait verbal aggression (p=0.008). In conclusion, the association between the studied CRP and CFH polymorphisms and personality traits further supports the association between the immune system and mental functions.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?