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Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF.

Journal article
Authors Clas Malmeström
Jan Lycke
Sara Haghighi
Oluf Andersen
Lena M S Carlsson
Hans Wadenvik
Bob Olsson
Published in Journal of neuroimmunology
Volume 196
Issue 1-2
Pages 159-65
ISSN 0165-5728
Publication year 2008
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Internal Medicine
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 159-65
Language en
Links dx.doi.org/10.1016/j.jneuroim.2008....
Keywords Adult, Antigens, CD8, genetics, metabolism, Antigens, Differentiation, T-Lymphocyte, genetics, metabolism, CD8-Positive T-Lymphocytes, metabolism, Dipeptidyl Peptidase I, genetics, metabolism, Female, Flow Cytometry, methods, Gene Expression, Gene Expression Regulation, physiology, Granzymes, blood, cerebrospinal fluid, genetics, Humans, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, cerebrospinal fluid, pathology, Oligonucleotide Array Sequence Analysis, methods, Perforin, genetics, metabolism, RNA, Messenger, metabolism
Subject categories Medical and Health Sciences

Abstract

MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses.

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