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Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis.

Journal article
Authors Henrik Zetterberg
Johan Jacobsson
Lars Rosengren
Kaj Blennow
Peter M Andersen
Published in Journal of the neurological sciences
Volume 273
Issue 1-2
Pages 67-9
ISSN 0022-510X
Publication year 2008
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 67-9
Language en
Subject categories Medical and Health Sciences


Amyotrophic lateral sclerosis (ALS) is a neurodegenerative syndrome with familial and sporadic forms. We conducted a study including 60 sporadic and 19 familial ALS patients, 206 reference patients with other neurological disorders and 1265 neurologically healthy controls to assess the Alzheimer-associated apolipoprotein E (APOE) epsilon4 gene variant as a possible risk factor for ALS. While no major influence of APOE epsilon4 on disease risk was detected, a gene dose-dependent effect with lower age at onset of sporadic ALS in epsilon4 carriers was found (p=0.027). These data support APOE epsilon4 as a subordinate contributing factor in ALS.

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