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Solution NMR structure determination of proteins revisited

Review article
Authors Martin Billeter
Gerhard Wagner
Kurt Wüthrich
Published in J. Biomol. NMR
Volume 42
Pages 155-158
Publication year 2008
Published at Department of Chemistry
Pages 155-158
Language en
Links www.springerlink.com/content/v15h64...
Keywords NMR structure determination of proteins, Protein biochemistry, Automation, Structural biology, Structural genomics
Subject categories Spectroscopy, Structural Biology, Molecular biophysics

Abstract

This ‘Perspective’ bears on the present state of protein structure determination by NMR in solution. The focus is on a comparison of the infrastructure available for NMR structure determination when compared to protein crystal structure determination by X-ray diffraction. The main conclusion emerges that the unique potential of NMR to generate high resolution data also on dynamics, interactions and conformational equilibria has contributed to a lack of standard procedures for structure determination which would be readily amenable to improved efficiency by automation. To spark renewed discussion on the topic of NMR structure determination of proteins, procedural steps with high potential for improvement are identified.

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