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Stunning of iodide transport by (131)I irradiation in cultured thyroid epithelial cells.

Journal article
Authors Per Postgård
Jakob Himmelman
Ulrika Lindencrona
Nirmal Bhogal
Dennis Wiberg
Gertrud Berg
Svante Jansson
Ernst Nyström
Eva Forssell-Aronsson
Mikael Nilsson
Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume 43
Issue 6
Pages 828-34
ISSN 0161-5505
Publication year 2002
Published at Institute of Selected Clinical Sciences, Department of Oncology
Institute of Selected Clinical Sciences, Department of Radiation Physics
Institute of Anatomy and Cell Biology
Institute of Internal Medicine, Dept of Medicine
Institute of Surgical Sciences, Department of Surgery
Pages 828-34
Language en
Keywords Animals, Biological Transport, Cells, Cultured, Iodides, pharmacokinetics, Iodine Radioisotopes, Radiation Dosage, Swine, Thyroid Gland, cytology, radiation effects
Subject categories Medical and Health Sciences


The existence of thyroid stunning (i.e., inhibited thyroidal iodide uptake after administration of diagnostic amounts of (131)I) is controversial and is currently a subject of debate. To our knowledge, the stunning phenomenon has not been investigated previously in vitro. METHODS: Growth-arrested porcine thyroid cells that formed a tight and polarized monolayer in a bicameral chamber were irradiated with 3-80 Gy (131)I present in the surrounding culture medium for 48 h. The iodide transport capacity after irradiation was evaluated 3 d later by measuring the transepithelial (basal to apical) flux of trace amounts of (125)I. RESULTS: The basal-to-apical (125)I transport decreased with increasing absorbed dose acquired from (131)I; a nearly 50% reduction was observed already at 3 Gy. Stable iodide at the same molarity as (131)I (10(-8) mol/L) had no effect on the (125)I transport. Cell number and epithelial integrity were not affected by irradiation. CONCLUSION: Stunning of iodide transport is detected after (131)I irradiation of cultured thyroid cells. The degree of inhibition of transport is dependent on the absorbed dose.

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