To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Taurine elevates dopamine… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine.

Journal article
Authors Mia Ericson
Anna C Molander
Rosita Stomberg
Bo Söderpalm
Published in The European journal of neuroscience
Volume 23
Issue 12
Pages 3225-9
ISSN 0953-816X
Publication year 2006
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 3225-9
Language en
Links dx.doi.org/10.1111/j.1460-9568.2006...
Keywords Animals, Dopamine, metabolism, Ganglionic Blockers, metabolism, Glycine Agents, metabolism, Male, Mecamylamine, Microdialysis, Neuromuscular Depolarizing Agents, metabolism, Nucleus Accumbens, anatomy & histology, metabolism, Piperidines, metabolism, Rats, Rats, Wistar, Receptors, Glycine, antagonists & inhibitors, metabolism, Strychnine, metabolism, Taurine, metabolism
Subject categories Pharmacology, Substance Abuse

Abstract

The mesolimbic dopamine (DA) system, projecting from the ventral tegmental area (VTA) to the nucleus accumbens (nAcc), is involved in reward-related behaviours and addictive processes, such as alcoholism and drug addiction. It was recently suggested that strychnine-sensitive glycine receptors (GlyR) in the nAcc regulate both basal and ethanol-induced mesolimbic DA activity via a neuronal loop involving endogenous activation of nicotinic acetylcholine receptors (nAChR) in the VTA. However, as the nAcc appears to contain few glycine-immunoreactive cell bodies or fibres, the question as to what may be the endogenous ligand for GlyRs in this brain region remains open. Here we have investigated whether the amino acid taurine could serve this purpose using in vivo microdialysis in awake, freely moving male Wistar rats. Local perfusion of taurine (1, 10 or 100 mm in the perfusate) increased DA levels in the nAcc. The taurine (10 mm)-induced DA increase was, similarly to that previously observed after ethanol, completely blocked by (i) perfusion of the competitive GlyR antagonist strychnine in the nAcc, (ii) perfusion of the nAChR antagonist mecamylamine (100 microm) in the VTA, and (iii) systemic administration of the acetylcholine-depleting drug vesamicol (0.4 mg/kg, i.p). The present results suggest that taurine may be an endogenous ligand for GlyRs in the nAcc and that the taurine-induced elevation of DA levels in this area, similarly to that observed after local ethanol, is mediated via a neuronal loop involving endogenous activation of nAChRs in the VTA.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?