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Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

Journal article
Authors Louise Nilsson
Nadine Binart
Mohammad Bohlooly-Yeganeh
Margareta Bramnert
Emil Egecioglu
Jon Kindblom
Paul Kelly
John J Kopchick
Christopher Ormandy
Charlotte Ling
Håkan Billig
Published in Biochemical and Biophysical Research Communications
Volume 331
Pages 1120–1126
Publication year 2005
Published at Institute of Physiology and Pharmacology, Dept of Physiology
Pages 1120–1126
Language en
Links doi:10.1016/j.bbrc.2005.04.026
Keywords Adiponectin; Adiponectin receptor; Prolactin; Growth hormone
Subject categories Physiology


Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice had elevated adiponectin levels, while PRL receptor deficient mice were unaffected. In conclusion, we demonstrate gene expression of AdipoR1 and AdipoR2 in human adipose tissue for the first time, and show that these are differentially regulated by PRL and GH. Both PRL and GH reduced adiponectin secretion in human adipose tissue in vitro and in mice in vivo. Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance.

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