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Nicotine-induced behavioral disinhibition and ethanol preference correlate after repeated nicotine treatment.

Journal article
Authors Peter Olausson
Mia Ericson
Elin Löf
Jörgen Engel
Bo Söderpalm
Published in European journal of pharmacology
Volume 417
Issue 1-2
Pages 117-23
ISSN 0014-2999
Publication year 2001
Published at Institute of Physiology and Pharmacology, Dept of Pharmacology
Pages 117-23
Language en
Keywords Analysis of Variance, Animals, Behavior, Animal, drug effects, Ethanol, pharmacology, Male, Maze Learning, drug effects, Motor Activity, drug effects, Nicotine, pharmacology, Rats, Rats, Wistar, Time Factors
Subject categories Pharmacology, Biological research on drug dependence, Neurobiology, Substance Abuse


This study investigated the effects of repeated daily nicotine (0.35 mg/kg; 15 days) treatment on behavioral inhibition and locomotor activity in the elevated plus-maze and on voluntary ethanol consumption. When challenged with nicotine before the test, rats pretreated with repeated nicotine spent more time on and made more entries onto the open arms of an elevated plus-maze than did vehicle-pretreated animals. The ethanol preference and intake, measured during 3 h after a nicotine injection, was also higher in the nicotine-pretreated animals. In ethanol consumption experiments, there was a positive correlation between the % time and % entries made onto open arms vs. the ethanol preference and intake. However, no correlation between the total number of entries made in the elevated plus-maze and the measures of ethanol consumption was observed. These findings suggest that the ability of repeated nicotine administration to increase ethanol consumption is related to development of a nicotine-induced reduction of inhibitory control rather than development of locomotor sensitization.

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