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On the site and mechanism of action of the anti-obesity effects of interleukin-6.

Journal article
Authors John-Olov Jansson
Kristina Wallenius
Ingrid Wernstedt
Claes Ohlsson
Suzanne L. Dickson
Ville Wallenius
Published in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Volume 13 Suppl A
Pages S28-32
ISSN 1096-6374
Publication year 2003
Published at Wallenberg Laboratory
Institute of Internal Medicine, Dept of Medicine
Institute of Internal Medicine
Institute of Internal Medicine, Dept of Body Composition and Metabolism
Institute of Physiology and Pharmacology, Dept of Physiology
Pages S28-32
Language en
Keywords Adipose Tissue, drug effects, Animals, Anti-Obesity Agents, pharmacology, Blood Glucose, metabolism, Body Weight, drug effects, Brain, drug effects, Energy Metabolism, drug effects, Injections, Intraventricular, Interleukin-6, pharmacology, physiology, Mice, Mice, Knockout, Obesity, drug therapy, metabolism, Oxygen Consumption, drug effects, Rats
Subject categories Medical and Health Sciences


We conducted an experimental study examining the site and mechanism of action of the anti-obesity effect of interleukin-6 (IL-6) in mice and rats. We used dual energy X-ray absorptiometry (DEXA) and computerized tomography to investigate the body composition of mice with knockout of the IL-6 gene and wild-type control mice. Rats were treated with IL-6 or vehicle through intracerebroventricular (ICV) cannulae. Energy expenditure was measured as oxygen consumption by indirect calorimetry in metabolic chambers. Results showed that the mice lacking IL-6 increased in body weight compared with wild-type mice from 6 months of age onward, although there was no marked difference in food intake between the pre-obese IL-6 knockout mice and the wild-type mice. IL-6 given as a single ICV injection to rats stimulated oxygen consumption; whereas, the same doses were ineffective when given peripherally. Chronic ICV IL-6 treatment decreased body weight and fat mass in rodents. Administration of IL-6 may decrease fat mass in mice and rats by stimulating energy expenditure at the CNS level, possibly in the hypothalamus.

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