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Effects of gastric distension on the cardiovascular system in rainbow trout (Oncorhynchus mykiss).

Journal article
Authors Henrik Seth
Erik Sandblom
Susanne Holmgren
Michael Axelsson
Published in American journal of physiology. Regulatory, integrative and comparative physiology
Volume 294
Issue 5
Pages R1648-56
ISSN 0363-6119
Publication year 2008
Published at Department of Zoology
Pages R1648-56
Language en
Links dx.doi.org/10.1152/ajpregu.00900.20...
Keywords Adrenergic alpha-Antagonists, pharmacology, Animals, Balloon Dilatation, Blood Pressure, drug effects, physiology, Cardiac Output, drug effects, physiology, Cardiovascular Physiology, Oncorhynchus mykiss, physiology, Physical Stimulation, Prazosin, pharmacology, Receptors, Adrenergic, alpha, physiology, Regional Blood Flow, drug effects, physiology, Stomach, physiology, Stroke Volume, drug effects, Vascular Capacitance, drug effects, physiology
Subject categories Animal physiology

Abstract

When animals feed, blood flow to the gastrointestinal tract increases to ensure an adequate oxygen supply to the gastrointestinal tissue and an effective absorption of nutrients. In mammals, this increase depends on the chemical properties of the food, as well as, to some extent, on the mechanical distension of the stomach wall. By using an inflatable nitrile balloon positioned in the stomach, we investigated the cardiovascular responses to mechanical stretch of the stomach wall in rainbow trout (Oncorhynchus mykiss). Distension with a volume equivalent to a meal of 2% of the body mass increased dorsal aortic blood pressure by up to 29%, and central venous blood pressure increased transiently nearly fivefold. The increase in arterial pressure was mediated by an increased vascular resistance of both the systemic and the intestinal circulation. Cardiac output, heart rate, and stroke volume (SV) did not change, and only transient changes in gut blood flow were observed. The increase in arterial pressure was abolished by the alpha-adrenergic antagonist prazosin, indicating an active adrenergic vasoconstriction, whereas the venous pressor response could be the consequence of a passive increase in intraperitoneal pressure. Our results show that mechanical distension of the stomach causes an instantaneous increase in general vascular resistance, which may facilitate a redistribution of blood to the gastrointestinal tract when chemical stimuli from a meal induce vasodilation in the gut circulation. The normal postprandial increase in gut blood flow in teleosts is, therefore, most likely partly dependent on mechanical stimuli, as well as on chemical stimuli.

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