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Recent outcomes and perspectives of the application of bone morphogenetic proteins in implant dentistry.

Journal article
Authors Luiz A Salata
Victoria Franke Stenport
Lars Rasmusson
Published in Clinical implant dentistry and related research
Volume 4
Issue 1
Pages 27-32
ISSN 1523-0899
Publication year 2002
Published at Institute of Surgical Sciences
Institute of Odontology
Institute of Odontology, Department of Prosthetic Dentistry/Dental Technology
Pages 27-32
Language en
Keywords Alveolar Ridge Augmentation, Animals, Bone Density, drug effects, Bone Morphogenetic Proteins, classification, pharmacology, therapeutic use, Dental Implantation, Endosseous, Dental Implants, Humans, Osseointegration, Osteogenesis, drug effects, Transforming Growth Factor beta, pharmacology, therapeutic use, Treatment Outcome, Wound Healing, drug effects
Subject categories Biomaterials


BACKGROUND: Since the discovery of bone morphogenetic proteins (BMPs), the number of related studies has increased substantially, and more recent outcomes have cast encouraging perspectives on their use in reconstructive surgery. PURPOSE: The aim of the present review was to summarize the present knowledge about the use of BMPs in conjunction with dental implants based on the literature. MATERIALS AND METHODS: Scientific articles dealing with the use of growth factors and bone healing with or without dental implants were searched for on MEDLINE and critically scrutinized. RESULTS: Thirty-nine scientific reports formed the base for the present review. Whereas the osteoinductive capability of BMPs is well documented, studies on their effects in implant dentistry are still incipient. Preclinical and clinical studies did not show outstandingly good outcomes of the application of BMPs compared with conventional treatments or controls. CONCLUSIONS: The number of studies in the field of dental implantology in which BMPs have been used is still too small for establishing clinical protocols of their use in order to improve a recipient bone bed prior to implant placement or to enhance the integration process of an implant.

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