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Enhanced spontaneous locomotor activity in bovine GH transgenic mice involves peripheral mechanisms

Journal article
Authors Mohammad Bohlooly-Yeganeh
Bob Olsson
Amel Gritli Linde
Ola Brusehed
Olle Isaksson
Claes Ohlsson
Bo Söderpalm
Jan Törnell
Published in Endocrinology
Volume 142
Issue 10
Pages 4560-4567
Publication year 2001
Published at Institute of Odontology, Department of Oral Biochemistry
Institute of Physiology and Pharmacology, Dept of Pharmacology
Institute of Internal Medicine
Institute of Physiology and Pharmacology, Dept of Physiology
Pages 4560-4567
Language en
Subject categories Molecular neurobiology, Neurophysiology, Cell and molecular biology

Abstract

Clinical and experimental studies indicate a role for GH in mechanisms related to anhedonia/hedonia, psychic energy, and reward. Recently we showed that transgenic mice with general overexpression of bovine GH display increased spontaneous locomotor activity. In the present study, we investigated whether this behavioral change is owing to a direct action of GH in the central nervous system or to peripheral GH actions. A transgenic construct, containing the glial fibrillary acidic protein promoter directing specific expression of bovine GH to the central nervous system, was designed. The central nervous system-specific expression of bovine GH in the glial fibrillary acidic protein-bovine GH transgenic mice was confirmed, but no effect on spontaneous locomotor activity was observed. Serum bovine GH levels were increased in glial fibrillary acidic protein-bovine GH transgenic mice but clearly lower than in transgenic mice with general overexpression of bovine GH. In contrast to the transgenic mice with general overexpression of bovine GH, glial fibrillary acidic protein-bovine GH mice did not display any difference in serum IGF-I levels. The levels of free T(3) and the conversion of the free T(4) to free T(3) were only increased in transgenic mice with general overexpression of bovine GH, but serum corticosterone levels were similarly increased in both transgenic models. These results suggest that free T(3) and/or IGF-I, affecting dopamine and serotonin systems in the central nervous system, may mediate the enhanced locomotor activity observed in transgenic mice with general overexpression of bovine GH.

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