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Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic Fibrosis

Chapter in book
Authors Gunnar C. Hansson
Malin E V Johansson
Martin Lidell
Published in Advances in Experimental Medicine and Biology
Pages 169-178
ISBN 978-0-387-23076-4
Place of publication Göteborg
Publication year 2005
Published at Institute of Medical Biochemistry
Pages 169-178
Language en
Links dx.doi.org/10.1007/0-387-23250-8_12
Subject categories Medical and Health Sciences

Abstract

The typical CF symptoms with viscous and trapped mucus are still lacking a full explanation. Here we suggest that the CF mucus become sticky and adherent to the epithelial cells by a covalent attachment of MUC2 and MUC5AC. We also suggest that the expression of MUC2 in the lungs could contribute to the CF phenotype. However, there are several unanswered questions before these suggestions can be proved. Among the most urgent ones are to show to what molecules the generated anhydride can attach or if the anhydride only has been hydrolyzed. Once this and other questions have been answered, one can start to address potential therapeutic approaches using recent advances in mucin knowledge.

Page Manager: Webmaster|Last update: 9/11/2012
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