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A family of putative transcription termination factors shared amongst metazoans and plants.

Journal article
Authors Tomas Linder
Chan Bae Park
Jordi Asin-Cayuela
Mina Pellegrini
Nils-Göran Larsson
Maria Falkenberg
Tore Samuelsson
Claes M Gustafsson
Published in Current genetics
Volume 48
Issue 4
Pages 265-9
ISSN 0172-8083
Publication year 2005
Published at Institute of Medical Biochemistry
Pages 265-9
Language en
Keywords Amino Acid Sequence, Animals, Basic-Leucine Zipper Transcription Factors, chemistry, genetics, Conserved Sequence, DNA-Binding Proteins, chemistry, genetics, Humans, Mammals, Molecular Sequence Data, Phylogeny, Plants, genetics, Sequence Alignment
Subject categories Medical and Health Sciences


The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.

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