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Studies of the central nervous system-derived CAD cell line, a suitable model for intraneuronal transport studies?

Journal article
Authors Yongling Li
Linda Xiu-E Hou
Annika Aktiv
Annica Dahlström
Published in Journal of neuroscience research
Volume 85
Issue 12
Pages 2601-9
ISSN 0360-4012
Publication year 2007
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 2601-9
Language en
Links dx.doi.org/10.1002/jnr.21216
Subject categories Medical and Health Sciences

Abstract

The CAD cell line is a variant of a CNS-derived Cath.a cell line established by targeted oncogenesis in transgenic mice. Cell differentiation of the cell line can be induced by "starvation," i.e., removal of serum from the culture medium (protein-free medium). The differentiated CAD cells extend long processes, which ultrastructurally contain abundant microtubules, intermediate filaments, and various synaptic vesicles/organelles in the varicose enlargements, thus resembling neurites. Histochemical studies demonstrated that the differentiated cells express a number of synaptic vesicle proteins, cytoskeletons, different neurotransmitter enzymes, neuropeptides, and glia proteins. The data suggest that the differentiated CAD cells may be a suitable model for studies of intraneuronal transport, recycling of receptors, and pharmacological investigations.

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