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Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia.

Journal article
Authors Li Zhang
Zhi-Hong Chi
Hao Ren
Ming Rong
Annica Dahlström
Liping Huang
Zhan-You Wang
Published in Brain research bulletin
Volume 74
Issue 4
Pages 278-83
ISSN 0361-9230
Publication year 2007
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 278-83
Language en
Links dx.doi.org/10.1016/j.brainresbull.2...
Subject categories Medical and Health Sciences

Abstract

In the present study, we showed for the first time the localization of ZNT7 immunoreactivity in the mouse dorsal root ganglion (DRG) by means of immunohistochemistry and confocal laser scanning microscopy. Our results revealed that ZNT7 immunoreactivity was abundantly expressed in the nerve cells of the mouse DRG. Strong ZNT7 immunoreactivity was predominantly distributed in the perinuclear region of positive cells, while the nuclei were devoid of staining. Double immunofluorescence labeling of ZNT7 and TGN38 revealed a colocalization of the two antigens in the Golgi apparatus. In addition, the presence of labile zinc ions was detected with in vivo zinc selenium autometallography (AMG). AMG observations showed that the zinc staining pattern was also predominately located in the perinuclear Golgi area, like the ZNT7 immunostaining pattern in the DRG. These observations strongly suggest that ZNT7 may play an important role in facilitating zinc transport into the Golgi apparatus from the cytosol in the mouse DRG.

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