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Nodule detection in digital chest radiography: summary of the RADIUS chest trial.

Journal article
Authors Markus Håkansson
Magnus Båth
Sara Börjesson
Susanne Kheddache
Mark Ruschin
Anders Tingberg
Sören Mattsson
Lars Gunnar Månsson
Published in Radiation protection dosimetry
Volume 114
Issue 1-3
Pages 114-20
ISSN 0144-8420
Publication year 2005
Published at Institute of Selected Clinical Sciences, Department of Radiation Physics
Institute of Selected Clinical Sciences, Department of Radiology
Pages 114-20
Language en
Keywords Artifacts, Humans, Image Processing, Computer-Assisted, Lung, pathology, radiography, Lung Neoplasms, diagnosis, radiography, Models, Anatomic, Monte Carlo Method, Observer Variation, ROC Curve, Radiographic Image Enhancement, methods, Radiographic Image Interpretation, Computer-Assisted, methods, Radiography, methods, Radiography, Thoracic, methods, Scattering, Radiation, Software, X-Rays
Subject categories Radiology, Radiological physics


As a part of the Europe-wide research project 'Unification of physical and clinical requirements for medical X-ray imaging'-governed by the Radiological Imaging Unification Strategies (RADIUS) Group-a major image quality trial was conducted by members of the group. The RADIUS chest trial aimed at thoroughly examining various aspects of nodule detection in digital chest radiography, such as the effects of nodule location, system noise, anatomical noise, and anatomical background. The main findings of the RADIUS chest trial concerning the detection of a lung nodule with a size in the order of 10 mm can be summarised as: (1) the detectability of the nodule is largely dependent on its location in the chest, (2) the system noise has a minor impact on the detectability at the dose levels used today, (3) the disturbance of the anatomical noise is larger than that of the system noise but smaller than that of the anatomical background and (4) the anatomical background acts as noise to a large extent and is the major image component affecting the detectability of the nodule.

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