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CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression

Journal article
Authors Christian X Andersson
Julia Fernandez-Rodriguez
Sirle Laos
Dan Baeckström
Rein Sikut
Anu Sikut
Gunnar C. Hansson
Published in Biochem. Biophys. Res. Commun.
Volume 316
Issue 1
Pages 12-17
Publication year 2004
Published at Institute of Medical Biochemistry
Pages 12-17
Language en
Links dx.doi.org/10.1016/j.bbrc.2004.02.0...
Subject categories Biological Sciences, Cell and Molecular Biology

Abstract

CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the beta-catenin target genes c-MYC and CyclinD1. The present results suggest that CD43 can be involved in nuclear signaling and via beta-catenin interaction be involved in cell proliferation.

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