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Circulating levels of cholecystokinin and gastrin-releasing peptide in rainbow trout fed different diets.

Journal article
Authors Elisabeth Jönsson
A. Forsman
K Ruohonen
Ingibjörg Einarsdottir
Barbro Egner
Björn Thrandur Björnsson
Published in General and Comparative Endocrinology
Volume 148
Issue 2
Pages 187-194
ISSN 0016-6480
Publication year 2006
Published at Department of Zoology
Pages 187-194
Language en
Links dx.doi.org/10.1016/j.ygcen.2006.02....
Keywords Postprandial response, Gastrointestinal peptides, CCK, GRP, Feed intake, Dietary lipid, Oncorhynchus mykiss
Subject categories Biological Sciences, Animal physiology

Abstract

Cholecystokinin (CCK) and gastrin-releasing peptide (GRP) are gastrointestinal peptides thought to be important regulators of intake and digestion of food in vertebrates. In this study, pre- and postprandial plasma levels of CCK and GRP were measured in rainbow trout (Oncorhynchus mykiss) by the establishment of homologous radioimmunoassays, and the hormonal levels assessed in relation to dietary lipid:protein ratio and food intake. Fish were acclimated to either a high protein/low lipid diet (HP/LL diet; 14.1% lipids) or a normal protein/high lipid diet (NP/HL diet; 31.4% lipids). On three consecutive sampling days, radio-dense lead-glass beads were included in the diets for assessment of feed intake. Fish were terminally sampled for blood and stomach contents prior to feeding at time 0, and at 0.3, 1, 2, 4, 6, and 24 h after feeding. There was a postprandial elevation of plasma CCK levels, which was most evident after 4 and 6 h. Fish fed the NP/HL diet had higher plasma CCK levels compared with those fed the HP/LL diet. Plasma CCK levels were not affected by the amount of food ingested. GRP levels in plasma were not influenced by sampling time, diet, or feed intake. The results indicate that the endocrine release of gastrointestinal CCK is increased during feeding and may be further influenced by the dietary lipid:protein ratio in rainbow trout. Plasma GRP levels, on the other hand, appear not to be influenced by feeding or diet composition.

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