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Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.

Journal article
Authors Anna Håkansson
Lars Westberg
Staffan Nilsson
Silvia Buervenich
Andrea Carmine
Björn Holmberg
Olof Sydow
Lars Olson
Bo Johnels
Elias Eriksson
Hans Nissbrandt
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume 133
Issue 1
Pages 88-92
ISSN 1552-4841
Publication year 2005
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Clinical Neurosciences
Institute of Physiology and Pharmacology, Dept of Pharmacology
Pages 88-92
Language en
Keywords Age of Onset, Alleles, Estrogen Receptor beta, genetics, Gene Frequency, Genetic Predisposition to Disease, genetics, Genotype, Humans, Interleukin-6, genetics, Linkage Disequilibrium, Parkinson Disease, genetics, Polymorphism, Single Nucleotide
Subject categories Medical and Health Sciences


The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (

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