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Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women.

Journal article
Authors Lars Westberg
Hoi-Por Ho
Fariba Baghaei
Staffan Nilsson
Jonas Melke
Roland Rosmond
Göran Holm
Per Björntorp
Elias Eriksson
Published in Clinical endocrinology
Volume 61
Issue 2
Pages 216-23
ISSN 0300-0664
Publication year 2004
Published at Department of Mathematical Statistics
Institute of Physiology and Pharmacology, Dept of Pharmacology
Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology
Pages 216-23
Language en
Links dx.doi.org/10.1111/j.1365-2265.2004...
Keywords Adult, Cohort Studies, DNA Transposable Elements, genetics, Estrogen Receptor alpha, Estrogen Receptor beta, Female, Follicular Phase, blood, Genotype, Humans, Polymorphism, Genetic, genetics, Polymorphism, Single Nucleotide, genetics, Prolactin, blood, Receptors, Estrogen, genetics, Receptors, Progesterone, genetics, Repetitive Sequences, Nucleic Acid, genetics, Smoking, genetics
Subject categories Medical and Health Sciences

Abstract

OBJECTIVE: Oestrogen and progesterone are known to influence the release of human prolactin. The present study was undertaken in order to investigate the possible influence of polymorphisms of the genes encoding the oestrogen receptor (ER)alpha, ERbeta and the progesterone receptor (PGR), on prolactin levels in premenopausal women. DESIGN AND MEASUREMENTS: Serum levels of prolactin were measured in the follicular phase of the menstrual cycle. Subjects were genotyped with respect to a TA repeat polymorphism of the ERalpha gene, a CA repeat polymorphism of the ERbeta gene, and two polymorphisms of the PGR gene: one insertion polymorphism (PROGINS) and one single nucleotide polymorphism (G331A). SUBJECTS: A population-based cohort of 270 42-year-old women. RESULTS: The CA repeat polymorphism of the ERbeta gene and the G331A polymorphism of the PGR gene appeared to be associated with prolactin levels. In contrast, we found no evidence for an influence of the PROGINS polymorphism of the PGR gene or the TA repeat polymorphism of the ERalpha gene on the levels of this hormone. CONCLUSIONS: These data suggest that genetic variants of both the ERbeta and the PGR may influence prolactin release.

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