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Association between the estrogen receptor beta gene and age of onset of Parkinson's disease.

Journal article
Authors Lars Westberg
Anna Håkansson
Jonas Melke
Haydeh Niazi Shahabi
Staffan Nilsson
S Buervenich
A Carmine
Jarl Ahlberg
M B Grundell
B Schulhof
K Klingborg
Björn Holmberg
O Sydow
L Olson
Bo Johnels
Elias Eriksson
Hans Nissbrandt
Published in Psychoneuroendocrinology
Volume 29
Issue 8
Pages 993-8
ISSN 0306-4530
Publication year 2004
Published at Department of Mathematical Statistics
Institute of Clinical Neurosciences
Institute of Physiology and Pharmacology, Dept of Pharmacology
Pages 993-8
Language en
Links dx.doi.org/10.1016/j.psyneuen.2003....
Keywords Adult, Age of Onset, Aged, Case-Control Studies, Chi-Square Distribution, Chromosomes, Human, Pair 14, genetics, Estrogen Receptor beta, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Odds Ratio, Parkinson Disease, epidemiology, genetics, Polymorphism, Single Nucleotide, genetics, Receptors, Estrogen, genetics, Sweden, epidemiology
Subject categories Medical and Health Sciences

Abstract

The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.

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