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The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin

Journal article
Authors Jens Renner
Irma Kruszelnicki
Beata Adamiak
Anthony C Willis
Edward Hammond
Stephen Su
Christopher Burns
Edward Trybala
Vito Ferro
Martin G Banwell
Published in Australian Journal of Chemistry
Volume 58
Issue 2
Pages 86-93
Publication year 2005
Published at Institute of Laboratory Medicine, Dept of Clinical Virology
Pages 86-93
Language en
Links dx.doi.org/10.1071/CH04273
Subject categories Medical and Health Sciences

Abstract

Two novel analogues, 2 and 3, of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion. The tetraacetate precursor, 12, of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses. Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic, anti-bacterial, and anti-viral effects.

Page Manager: Webmaster|Last update: 9/11/2012
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