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Cyclooxygenase-2 polymorphisms in Parkinson's disease.

Journal article
Authors Anna Håkansson
Olle Bergman
Cecilia Chrapkowska
Lars Westberg
Andrea Carmine Belin
Olof Sydow
Bo Johnels
Lars Olson
Björn Holmberg
Hans Nissbrandt
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Volume 144
Issue 3
Pages 367-9
ISSN 1552-4841
Publication year 2007
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 367-9
Language en
Links dx.doi.org/10.1002/ajmg.b.30449
Keywords Adult, Aged, Case-Control Studies, Cyclooxygenase 2, genetics, Female, Gene Frequency, Genotype, Humans, Linkage (Genetics), Male, Middle Aged, Parkinson Disease, genetics, Polymorphism, Single Nucleotide, Sex Characteristics
Subject categories Molecular neurobiology, Neurology

Abstract

Accumulating evidence indicate that cyclooxygenase-2 (COX-2) is of pathophysiological importance for the neurodegeneration in Parkinson's disease (PD). For example, in a large epidemiological study, use of NSAIDs was associated with a lower risk of PD. Genetic variants of the COX-2 gene might therefore influence the risk of developing the disease. The genotype distribution of four common single nucleotide polymorphisms (SNPs) in the COX-2 gene (rs689466:A496G, rs20417:G926C, rs5277:G3050C, rs5275:C8473T) was analyzed in PD patients and control subjects in a Swedish population. No differences could be seen between the PD-patient and controls regarding the A496G, G926C, and G3050C SNPs, but the allele frequency of the C8473T SNP was found to differ when male patients were compared to controls (P = 0.007). In females no difference could be seen between PD-patients and controls. In conclusion, the results suggest a possible influence of the COX-2 C8473T SNP in PD, although it only seems to be of importance in men.

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